PTSD
Comparison Between Cannabidiol And Sertraline For The Modulation Of Post-Traumatic Stress Disorder-Like Behaviors And Fear Memory In Mice
Xiao Han, Xiankui Song, Dake Song, Guanbo Xie, Hongyan Guo, Ning Wu, Jin Li (April 2022)
Post-traumatic stress disorder (PTSD) is characterized by poor adaptation to a traumatic experience and disturbances in fear memory regulation, and currently lacks effective medication. Cannabidiol is a main constituent of Cannabis sativa; it has no psychotomimetic effects and has been implicated in modulating fear learning in mammals. Using a mouse PTSD model, we investigated the effects of CBD on PTSD-like behaviors and the modulation of trauma-related fear memory, a crucial process leading to core symptoms of PTSD.
CBD produced anti-PTSD-like actions in mice and disrupted trauma-related fear memory by interfering with multiple aspects of fear memory processing. These findings indicate that CBD may be a promising candidate for treating PTSD.
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Cannabidiol and the Corticoraphe Circuit in Post-Traumatic Stress Disorder
Claire Alexander, Maryam Vasefi (August 2021)
Chronic CBD will treat PTSD by restoring stability to the corticoraphe circuit. In other words, chronic CBD administration will restore mPFC activity via enhanced release of 5-HT by DRN neurons. This mechanism of CBD was observed in rodent models of depression (Silote et al., 2019, Linge et al., 2016), however this mechanism slightly differs for PTSD. Due to enhanced endocannabinoid signaling, we suggest that corticoraphe signaling will be stabilized by AEA regulation of 5-HT release in the DRN when needed. CBD will potentiate fear extinction via a DRN mechanism, as it will reduce amygdala hyperactivity and restore mPFC activity, so that they may appropriately participate in fear extinction.
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Use of Cannabinoids for the Treatment of Patients with Post-Traumatic Stress Disorder
Marika L. Forsythe, Andrew J. Boileau (March 2021)
For this review, four cohort studies, four randomized clinical trials, one case report, and one case series were obtained from PubMed within the last 10 years. Cannabis extracts, tetrahydrocannabinol (THC) and canna-bidiol (CBD), and synthetic cannabinoids were used in the studies to target the cannabinoid receptors 1 and 2. Cannabinoids were shown to improve overall PTSD symptoms, including sleep quality and quantity, hyperarousal, and treatment-resistant nightmares. When participants were undergoing extinction training, cannabinoids given within the same time interval enhanced consolidation and retention.
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Intranasal Temperature-Sensitive Hydrogels of Cannabidiol Inclusion Complex for the Treatment of Post-Traumatic Stress Disorder
Lulu Pang, Siqing Zhu, Jinqiu Ma, Lin Zhu, Yijing Liu, Ge Ou, Ruiteng Li, Yaxin Wang, Yi Liang, Xi Jin, Lina Du, Yiguang Jin (January 2021)
Post-traumatic stress disorder (PTSD) is a psychiatric disease that seriously affects brain function. Currently, selective serotonin reuptake inhibitors (SSRIs) are used to treat PTSD clinically but have decreased efficiency and increased side effects. In this study, nasal cannabidiol inclusion complex temperature-sensitive hydrogels (CBD TSGs) were prepared and evaluated to treat PTSD.
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Use of Medicinal Cannabis and Synthetic Cannabinoids in Post-Traumatic Stress Disorder (PTSD): A Systematic Review
Laura Orsolini, Stefania Chiappini, Umberto Volpe, Domenico De Berardis, Roberto Latini, Gabriele Duccio Papanti and John Martin Corkery (August 2019)
Post-traumatic stress disorder (PTSD) is a common psychiatric disorder resulting from a traumatic event, is manifested through hyperarousal, anxiety, depressive symptoms, and sleep disturbances. Despite several therapeutic approaches being available, both pharmacological and psychological, recently a growing interest has developed in using cannabis and synthetic cannabinoids stems from their consideration as more efficient and better tolerated alternatives for the treatment of this condition. The present paper aims to evaluate the clinical and therapeutic potentials of medical cannabis and synthetic cannabinoids in treating PTSD patients.
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Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials
Rafael M. Bitencourt and Reinaldo N. Takahashi (July 2018)
Post-traumatic stress disorder (PTSD) is characterized by poor adaptation to a traumatic experience. This disorder affects approximately 10% of people at some point in life. Current pharmacological therapies for PTSD have been shown to be inefficient and produce considerable side effects. Since the discovery of the involvement of the endocannabinoid (eCB) system in emotional memory processing, pharmacological manipulation of eCB signaling has become a therapeutic possibility for the treatment of PTSD. Cannabidiol (CBD), a phytocannabinoid constituent of Cannabis sativa without the psychoactive effects of Δ9-tetrahydrocannabinol, has gained particular attention. This paper reviews the therapeutic potential of CBD in the treatment of PTSD. It starts from the first evidence obtained in animal studies (“bench research”) and proceeds to knowledge gathered in human trials (“confirmation in human trials”).
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Endocannabinoid System in Posttraumatic Stress Disorder (PTSD) Early After Traumatic Injury
Terri deRoon-Cassini, Samantha Chesney, Cecilia Hillard (April 2018)
In the immediate aftermath of injury it is unclear who demonstrates risk for posttraumatic stress disorder (PTSD). Pre-clinical data suggests the endocannabinoid signaling system responds to stress and acts as a buffer after trauma. The purpose of the present study was: 1) evaluate the role of early circulating endocannabinoid (2-AG, AEA) functioning in 6-month PTSD, and 2) evaluate polymorphisms of the cannabinoid receptor type 1 (CB1) and fatty acid amide hydrolase (FAAH) genes to determine differential PTSD risk.
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Investigating Endocannabinoid Mechanisms in Posttraumatic Stress Disorder: Neuroimaging Studies With the Novel Fatty Acid Amide Hydrolase Probe, [11C]CURB
IsabelleBoileau, DuncanWestwood, DonaldRichardson, ShawnRhind, Rachel F.Tyndale, RuthLanius, RichardBazinet, Nancy J.Lobaugh, SylvainHoule (April 2018)
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Fatty Acid Amide Hydrolase (FAAH), the enzyme responsible for terminating endocannabinoid signaling, is believed to be a key modulator of fear-related circuitry and to be increased in post-traumatic stress disorder (PTSD). This enzyme and other components of the endocannabinoid system are drug targets for stress-related conditions.
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Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats
Maria Morena, Andrea Berardi, Paola Colucci, Maura Palmery, Viviana Trezza, Matthew N Hill and Patrizia Campolongo (December 2017)
Exposure to a traumatic event may result in the development of post-traumatic stress disorder (PTSD). Endocannabinoids are crucial modulators of the stress response, interfere with excessive retrieval and facilitate the extinction of traumatic memories. Exposure therapy, combined with pharmacotherapy, represents a promising tool for PTSD treatment. We investigated whether pharmacological manipulations of the endocannabinoid system during extinction learning ameliorates the behavioral changes induced by trauma exposure. Rats were exposed to inescapable footshocks paired with social isolation, a risk factor for PTSD.
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Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder
Matthew N Hill, Patrizia Campolongo, Rachel Yehuda and Sachin Patel (July 2017)
Here we review the current state of knowledge regarding the effects of cannabis and cannabinoids in PTSD and the preclinical and clinical literature on the effects of cannabinoids and endogenous cannabinoid signaling systems in the regulation of biological processes related to the pathogenesis of PTSD. Potential therapeutic implications of the reviewed literature are also discussed. Finally, we propose that a state of endocannabinoid deficiency could represent a stress susceptibility endophenotype predisposing to the development of trauma-related psychopathology and provide biologically plausible support for the self-medication hypotheses used to explain high rates of cannabis use in patients with trauma-related disorders.
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The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder (PTSD)
Viviana Trezza and Patrizia Campolongo (August 2013)
Endocannabinoids regulate affective states and participate in memory consolidation, retrieval, and extinction. Clinical findings showing a relationship between Cannabis use and PTSD, as well as changes in endocannabinoid activity in PTSD patients, further suggest the existence of a link between endocannabinoids and maladaptive brain changes after trauma exposure. Along these lines, we suggest that endocannabinoid degradation inhibitors may be an ideal therapeutic approach to simultaneously treat the emotional and cognitive features of PTSD, avoiding the unwanted psychotropic effects of compounds directly binding cannabinoid receptors.
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If you proceed to article you will be leaving the CB1 Capital Management website to access a website hosted by a party unrelated to CB1 Capital Management. CB1 Capital Management assumes no responsibility for the accuracy of any of these studies nor does CB1 assume any obligation to update any of these studies based on subsequent research.