Atherosclerosis
Cannabidiol Exerts a Neuroprotective and Glia-Balancing Effect in the Subacute Phase of Stroke
Erika Meyer, Phillip Rieder, Davide Gobbo, Gabriella Candido, Anja Scheller, Rúbia Maria Weffort de Oliveira and Frank Kirchhoff (October 2022)
Overall, the present findings suggest that the functional and structural protective effects of cannabidiol (CBD) are closely associated with anti-inflammatory activity in the subacute phase of ischemia. Even though the mechanisms of action of CBD are not yet fully understood, our data have heuristic value to inspire further studies investigating the effect of CBD using different treatment schedules, for example, when administered for longer periods or later after the onset of ischemia. In conclusion, our data highlight the potential of CBD as a neuroprotective compound in stroke.
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Cannabis Seed Oil Alleviates Experimental Atherosclerosis by Ameliorating Vascular Inflammation in Apolipoprotein-E-Deficient Mice
Wenjing Huang, Zhujun Zeng, Yan Lang, Xia Xiang, Gaofu Qi, Gan Lu, Xiangliang Yang (May 2021)
In recent decades, epidemiological, clinical, and experimental studies have demonstrated that a diet with antioxidant or anti-inflammatory function plays a central role in the prevention of atherosclerosis (AS). The purpose of this study was to explore the effects of Cannabis seed oil (CO) administration on in vitro antioxidant capacity as well as blood lipid profiles, lipid peroxidation, inflammatory response, and endothelial cell integrity. The results show that CO administration reduced the levels of serum triglycerides and low-density lipoprotein cholesterol at week 6. Additionally, a decrease in serum tumor necrosis factor α and nitric oxide was also observed. Moreover, results from CD31 staining and scanning electron microscopy revealed that CO treatment alleviated the endothelial cell damage and lipid deposition induced by a high-cholesterol diet. The ratio of lesion area to the total aorta area was 19.57% for the CO group, which was lower than the PBS control group (24.67%). Collectively, CO exerted anti-atherosclerotic effects by modulating serum lipid profiles and inflammatory responses and improving endothelial cell integrity and arterial lipid deposition. The results provide a promising preventive strategy for the early progression of AS.
Important Notice
If you proceed to article you will be leaving the CB1 Capital Management website to access a website hosted by a party unrelated to CB1 Capital Management. CB1 Capital Management assumes no responsibility for the accuracy of any of these studies nor does CB1 assume any obligation to update any of these studies based on subsequent research.
The Endocannabinoid System and Heart Disease: The Role of Cannabinoid Receptor Type 2.
M. Hebi and D.P. Thewke (February 2018)
Recent studies have shed light on a protective role of CB2 in cardiovascular disease, an ailment which currently takes more lives each year in Western countries than any other disease or injury. By use of CB2 knockout mice and CB2-selective ligands, knowledge of how CB2 signaling affects atherosclerosis and ischemia has been acquired, providing a major stepping stone between basic science and translational clinical research. Here, we summarize the current understanding of the endocannabinoid system in human pathologies and provide a review of the results from preclinical studies examining its function in cardiovascular disease, with a particular emphasis on possible CB2-targeted therapeutic interventions to alleviate atherosclerosis.
Important Notice
If you proceed to article you will be leaving the CB1 Capital Management website to access a website hosted by a party unrelated to CB1 Capital Management. CB1 Capital Management assumes no responsibility for the accuracy of any of these studies nor does CB1 assume any obligation to update any of these studies based on subsequent research.
The Endocannabinoid System in Cardiovascular Function: Novel Insights and Clinical Implications
Salvador Sierra, Natasha Luquin, Judith Navarro-Otano (December 2017)
Over the last years, increasing evidence from basic and clinical research supports the role of the eCB system in cardiovascular function. Whereas new discoveries are paving the way for the identification of novel drugs and therapeutic targets, the close cooperation of researchers, clinicians and pharmaceutical companies is needed to achieve successful outcomes.
Important Notice
If you proceed to article you will be leaving the CB1 Capital Management website to access a website hosted by a party unrelated to CB1 Capital Management. CB1 Capital Management assumes no responsibility for the accuracy of any of these studies nor does CB1 assume any obligation to update any of these studies based on subsequent research.
Translating Endocannabinoid Biology into Clinical Practice: Cannabidiol for Stroke Prevention
Scharf, Eugene L. (October 2017)
This speculative synthesis explores the current state of knowledge of the ECS and suggests CBD as a therapeutic candidate for stroke prevention by exerting favorable augmentation of the homeostatic effects of the ECS and, in turn, improving the metabolic syndrome, while simultaneously stalling the development of atherosclerosis.
Important Notice
If you proceed to article you will be leaving the CB1 Capital Management website to access a website hosted by a party unrelated to CB1 Capital Management. CB1 Capital Management assumes no responsibility for the accuracy of any of these studies nor does CB1 assume any obligation to update any of these studies based on subsequent research.
The Role of the Endocannabinoid System in the Pathogenesis of Atherosclerosis
Steffens, Sabine (March 2012)
A dysregulation of the endocannabinoid system has been linked to a variety of pathologic conditions, including atherosclerosis and its related cardiovascular risk factors, obesity, dyslipidemia and diabetes. The endocannabinoid system comprises at least two distinct membrane receptors, CB1 and CB2, their endogenous ligands (named endocannabinoids) as well as enzymes for ligand biosynthesis and inactivation. It is well established that endocannabinoids are synthesized and released ‘‘on demand’’ and that this process can be regulated both physiologically and under pathological conditions. As regards cardiovascular disease, blocking of CB1 receptors reduces several cardiometabolic risk factors in rodents and humans, indicating a potential relevance for the process of atherosclerosis. A modulation of endocannabinoid levels was reported in patients with coronary artery disease as well as in atherosclerotic mice. The first evidence for a causal role of endocannabinoid-mediated CB1 activation in atherosclerosis has been provided in an experimental mouse study.
Important Notice
If you proceed to article you will be leaving the CB1 Capital Management website to access a website hosted by a party unrelated to CB1 Capital Management. CB1 Capital Management assumes no responsibility for the accuracy of any of these studies nor does CB1 assume any obligation to update any of these studies based on subsequent research.